Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats
| Autor: | Francine Duchatsch, Carlos Alberto Vicentini, Anderson G. Macedo, Sandra Lia do Amaral, Thalles Fernando Rocha Ruiz, Danyelle S. Miotto |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Estadual Paulista (UNESP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty ACE inhibitors hypertension Physical Exertion Neovascularization Physiologic Lumen (anatomy) Angiotensin-Converting Enzyme Inhibitors 030204 cardiovascular system & hematology physical training 03 medical and health sciences 0302 clinical medicine Rats Inbred SHR Internal medicine Heart rate Perindopril Animals Medicine Myocyte Arterial Pressure Rats Wistar Antihypertensive Agents Pharmacology Soleus muscle business.industry Skeletal muscle Disease Models Animal 030104 developmental biology Endocrinology Blood pressure medicine.anatomical_structure Hypertension Cardiology and Cardiovascular Medicine business Perfusion medicine.drug circulatory and respiratory physiology |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Web of Science |
| Popis: | Made available in DSpace on 2022-04-28T17:21:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Sympathetic activity, arteriolar structure, and angiogenesis are important mechanisms modulating hypertension and this study aimed to analyze the effects of perindopril treatment, associated or not with exercise training, on the mechanisms that control blood pressure (BP) in hypertensive rats. Spontaneously hypertensive rats (SHR) were allocated into 4 groups: 1/sedentary (S); 2/perindopril (P, 3.0 mg/kg/d); 3/trained (T); and 4/trained + perindopril (TP). Wistar rats were used as normotensive sedentary control group. SHR were assigned to undergo a treadmill training (T) or were kept sedentary. Heart rate, BP, sympathetic activity to the vessels (LF-SBP), and skeletal muscle and myocardial morphometric analyses were performed. BP was significantly lower after all 3 strategies, compared with S and was accompanied by lower LF-SBP (-76%, -53%, and -44%, for P, T, and TP, respectively). Arteriolar vessel wall cross-sectional area was lower after treatments (-56%, -52%, and -56%, for P, T, and TP, respectively), and only TP presented higher arteriolar lumen area. Capillary rarefaction was present in soleus muscle and myocardium in S group and both trained groups presented higher vessel density, although perindopril attenuated this increase in soleus muscle. Although myocyte diameter was not different between groups, myocardial collagen deposition area, higher in S group, was lower after 3 strategies. In conclusion, we may suggest that perindopril could be an option for the hypertensive people who practice exercise and need a specific pharmacological treatment to reach a better BP control, mainly because training-induced angiogenesis is an important response to facilitate blood flow perfusion and oxygen uptake and perindopril did not attenuate this response. PIPGCF UFSCar UNESP, Joint Grad Program Physiol Sci, Sao Carlos, SP, Brazil Inst Biosci Humanities & Exact Sci UNESP, Sch Sci, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil UNESP, Sch Sci, Dept Biol Sci, Bauru, SP, Brazil UNESP, Sch Sci, Dept Phys Educ, Bauru, SP, Brazil PIPGCF UFSCar UNESP, Joint Grad Program Physiol Sci, Sao Carlos, SP, Brazil Inst Biosci Humanities & Exact Sci UNESP, Sch Sci, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil UNESP, Sch Sci, Dept Biol Sci, Bauru, SP, Brazil UNESP, Sch Sci, Dept Phys Educ, Bauru, SP, Brazil FAPESP: 2017/00509-1 CAPES: 001 CAPES: 1692103 CAPES: 88882.426908/2019-01 FAPESP: 2017/14405-3 |
| Databáze: | OpenAIRE |
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