A fatal anaemia in splenectomized irradiated mice protected with isogenic spleen colony cells
| Autor: | Leonard J. Cole, John H. L. Playfair |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Multidisciplinary
Anemia medicine.medical_treatment Splenectomy Spleen Biology In Vitro Techniques medicine.disease Molecular biology Transplantation Mice Radiation Injuries Experimental Lymphatic system Normal bone medicine.anatomical_structure Radiation Protection Immunology medicine Animals Bone marrow Bone Marrow Transplantation |
| Zdroj: | Nature. 206(982) |
| ISSN: | 0028-0836 |
| Popis: | THE work of Till and McCulloch et al.1,2 has established the existence in mouse bone marrow of a cell-type capable of proliferating in the spleens of lethally irradiated isogenic mice, and of forming visible colonies, or nodules, which contain both differentiated haemopoietic cells and more ‘colony-forming units’. During an investigation in this laboratory, of the ability of cells taken from such colonies to protect other lethally irradiated recipients, it was noticed that prior splenectomy of the recipients markedly reduced survival. In contrast, we have found that when normal bone marrow cells are used, prior splenectomy generally improves survival. The following experiment was therefore carried out |
| Databáze: | OpenAIRE |
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