Suspension polymerization for preparation of timed-release dosage forms
| Autor: | Roger W. Croswell, Charles H. Becker |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Chromatography
Time Factors Polymers digestive oral and skin physiology Pharmaceutical Science Expanded polystyrene Dosage form Acetaminophen Styrenes chemistry.chemical_compound chemistry Drug Stability Solubility Blowing agent Spectrophotometry Delayed-Action Preparations medicine Polystyrenes Suspension polymerization Dissolution testing Polystyrene Dissolution medicine.drug Tablets |
| Zdroj: | Journal of pharmaceutical sciences. 63(3) |
| ISSN: | 0022-3549 |
| Popis: | An investigation was undertaken to develop a process, utilizing suspension polymerization, for the production of timed-release medicated dosage forms. The effects of production variables upon dissolution of acetaminophen from these dosage forms were studied. Nonexpanded spherical polystyrene beads produced in the presence of acetaminophen exhibited no timed release of medication. However, timed release of medicament was observed when spherical polystyrene beads produced in the absence of acetaminophen were expanded with the aid of a blowing agent and subsequently allowed to absorb medicament. In general, 64% of the available drug was released from the free expanded polystyrene beads within the 1st hr of dissolution, with an additional 29% being released by the conclusion of dissolution testing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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