Polymorphism of the promoter region of prostacyclin synthase gene is not related to essential hypertension
| Autor: | Duolikun Rehemudula, Mikano Sato, Katsuo Kanmatsuse, Yukie Takahashi, Jiro Uwabo, Masayoshi Soma, Hideko Tobe, Yoichi Izumi, Masako Kunimoto, Tomohiro Nakayama |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Genotype Prostacyclin Essential hypertension Prostacyclin synthase Cytochrome P-450 Enzyme System Gene Frequency Polymorphism (computer science) Internal Medicine medicine Humans Allele Isomerases Promoter Regions Genetic Allele frequency Genetics Polymorphism Genetic biology Promoter Middle Aged medicine.disease Intramolecular Oxidoreductases Variable number tandem repeat Tandem Repeat Sequences Hypertension biology.protein Female medicine.drug |
| Zdroj: | American Journal of Hypertension. 14:409-411 |
| ISSN: | 0895-7061 |
| DOI: | 10.1016/s0895-7061(00)01256-5 |
| Popis: | An impaired synthesis of prostacyclin has been implicated in the development of essential hypertension (EH). We therefore investigated whether there is an association between the prostacyclin synthase (PGIS) gene and EH using a variable number of tandem repeats (VNTR) polymorphism in the promoter region that influences transcriptional activity of this gene. A total of 125 patients with EH and 125 age-matched subjects with normal blood pressure were studied. The number of VNTR of the five alleles ranged from 3 to 7 repeats in the 250 unrelated Japanese subjects. The allele frequency distribution in the two groups were not significantly different. Thus, this VNTR polymorphism in the PGIS gene is not associated with EH. |
| Databáze: | OpenAIRE |
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