Bupivacaine free plasma levels in children after caudal anaesthesia: influence of pretreatment with diazepam?

Autor:	B. Bruguerolle, B. Rousset-Rouviere, G. Morisson-Lacombe, E. Giaufre, C. Arnaud
Rok vydání:	1990
Předmět:	Anesthesia Epidural medicine.drug_class Caudal anaesthesia Pharmacology medicine Distribution (pharmacology) Humans heterocyclic compounds Pharmacology (medical) Drug Interactions Child Bupivacaine Diazepam Chemistry Local anesthetic digestive oral and skin physiology Plasma levels Drug interaction Anesthesia Child Preschool Free form Anesthesia Caudal Preanesthetic Medication medicine.drug Protein Binding
Zdroj:	Fundamentalclinical pharmacology. 4(2)
ISSN:	0767-3981
Popis:	Summary— Diazepam-induced modifications in bupivacaine distribution have been noted in previously reported data investigating the influence of diazepam on bupivacaine plasma levels in children undergoing surgery under caudal block with a mixture of lignocaine and bupivacaine. Possible diazepam-induced changes in protein binding were therefore examined in this study. Our data did not demonstrate significant modifications in bupivacaine protein binding when diazepam is used concomitantly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b6be208560efe816622ed2a1273fd0 https://pubmed.ncbi.nlm.nih.gov/2351365 Zobrazit plný text záznamu Plný text