Research progress on proteasome subunits in regulating occurrence and development of hepatocellular carcinoma
Autor: | Jingyi Hu, Yang Liu, Qingqing Wang |
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Rok vydání: | 2021 |
Předmět: |
STAT3 Transcription Factor
Cell signaling Proteasome Endopeptidase Complex Carcinoma Hepatocellular biology Chemistry Liver Neoplasms General Medicine Cell biology Proteasome Cell Line Tumor STAT protein biology.protein E2F1 Humans GRB2 STAT3 Protein kinase B Proteasome regulatory particle Cell Proliferation Signal Transduction Research Article |
Zdroj: | Zhejiang Da Xue Xue Bao Yi Xue Ban |
ISSN: | 1008-9292 |
Popis: | Proteasome is the eukaryotic organelle responsible for degradation of short-lived proteins and involved in maintaining cellular protein homeostasis. It has been reported that during the occurrence and development of hepatocellular carcinoma (HCC), the regulatory particle subunits of proteasome regulate a series of tumor-related proteins, and proliferation, survival-associated signaling molecules, including PTEN gene, P53, Bcl-2, Bcl-2 interacting mediator of cell death (Bim), cyclin-dependent kinase 4(CDK4), transforming growth factor β receptor (TGFBR), E2F1, growth factor receptor-bound protein 2 (GRB2) . Meanwhile, these subunits regulate some tumor-associated pathway protein, such as signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT), inducing their malfunction to promote the occurrence, proliferation, invasion and metastasis of HCC. The core particle subunits are more to perform the degradation of HCC-related proteins, so inhibitors targeting the core particle show a good anti-tumor effect. This review summarizes the current research progress on the regulation and mechanism of proteasome subunits in promoting the occurrence and development of HCC. |
Databáze: | OpenAIRE |
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