Members 6B and 14 of the TNF receptor superfamily in multiple sclerosis predisposition
| Autor: | R. Arroyo, Fiona Blanco-Kelly, E G de la Concha, Miguel Lucas, Antonio Alcina, María M. Abad-Grau, Oscar Fernández, Roberto Alvarez-Lafuente, Elena Urcelay, Fuencisla Matesanz, V. De Las Heras |
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| Rok vydání: | 2010 |
| Předmět: |
Multiple Sclerosis
Genotype Herpesvirus 6 Human Immunology Disease Biology Arthritis Rheumatoid Mediator Crohn Disease Genetics medicine Humans Genetic Predisposition to Disease Receptor Genotyping Gene Genetics (clinical) Polymorphism Genetic Multiple sclerosis Receptors Tumor Necrosis Factor Member 6b medicine.disease Virology Viral replication Spain Rheumatoid arthritis Receptors Tumor Necrosis Factor Member 14 |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1476-5470 1466-4879 |
| DOI: | 10.1038/gene.2010.42 |
| Popis: | TNFRSF6B and TNFRSF14 genes were recently associated with Crohn's disease and rheumatoid arthritis. TNFRSF14 is known as herpes virus entry mediator (HVEM), and herpes viruses have been involved in the aetiology of multiple sclerosis (MS). MS patients present human herpes virus 6 (HHV6) in active plaques and increased antibody responses to HHV6. We aimed to ascertain the role of these genes in MS susceptibility and to investigate the relationship of the gene encoding the widely expressed HVEM receptor with the active replication of HHV6 found in some MS patients. Genotyping of 1370 Spanish MS patients and 1715 ethnically matched controls was performed. HHV6A DNA levels (surrogate of active viral replication) were analysed in serum of MS patients during a 2-year follow-up. Both polymorphisms were associated with MS predisposition, with stronger effect in patients with HHV6 active replicationTNFRSF6B-rs4809330 A: P=0.028, OR1.13; TNFRSF14-rs6684865 A: overall P=0.0008, OR=1.2; and HHV6-positive patients vs controls: P=0.017, OR=1.69. © 2011 Macmillan Publishers Limited All rights reserved. |
| Databáze: | OpenAIRE |
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