Prognostic value of right atrial dilation in patients with pulmonary embolism

Autor: Rolf Wachter, Gerd Hasenfuß, Mareike Lankeit, Markus H. Lerchbaumer, Galit Aviram, Lukas Hobohm, Aaron Thielmann, Laura Steimke, Stavros Konstantinides, Matthias Ebner, Carmen Sentler, Karsten Keller, Bernd Hamm, Joachim Lotz, Nina I.J. Rogge, Christian Ritter
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: ERJ Open Research, Vol 7, Iss 2 (2021)
ERJ Open Research
article-version (VoR) Version of Record
ISSN: 2312-0541
Popis: Aims Right atrial (RA) dilation and stretch provide prognostic information in patients with cardiovascular diseases. We investigated the prevalence, confounding factors and prognostic relevance of RA dilation in patients with pulmonary embolism (PE). Methods Overall, 609 PE patients were consecutively included in a prospective single-centre registry between September 2008 and August 2017. Volumetric measurements of heart chambers were performed on routine non-electrocardiographic-gated computed tomography and plasma concentrations of mid-regional pro-atrial natriuretic peptide (MR-proANP) measured on admission. An in-hospital adverse outcome was defined as PE-related death, cardiopulmonary resuscitation, mechanical ventilation or catecholamine administration. Results Patients with an adverse outcome (11.2%) had larger RA volumes (median 120 (interquartile range 84–152) versus 102 (78–134) mL; p=0.013), RA/left atrial (LA) volume ratios (1.7 (1.2–2.4) versus 1.3 (1.1–1.7); p
RA dilation is a frequent finding but its prognostic performance appears inferior compared to other risk stratification markers. MR-proANP predicts an adverse outcome but elevation does not appear to be caused by RA dilation in a relevant proportion. https://bit.ly/3q55dqy
Databáze: OpenAIRE