Matrix metalloproteinase‐2, ‐7, and ‐9 activities in dogs with idiopathic pulmonary fibrosis compared to healthy dogs and dogs with other respiratory diseases

Autor: O. L. Merita Määttä, HP Laurila, Saila Holopainen, Minna M. Rajamäki, Liisa Lilja-Maula, Sanna Johanna Viitanen, Kaisa Aaltonen
Přispěvatelé: Equine and Small Animal Medicine, Helsinki One Health (HOH), Departments of Faculty of Veterinary Medicine, Hannes Tapani Lohi / Principal Investigator, Small Animal Hospital, Minna Marjaana Rajamäki / Principal Investigator, University Management
Rok vydání: 2020
Předmět:
Chronic bronchitis
PROGNOSIS
MATRILYSIN
PATHOGENESIS
Standard Article
030204 cardiovascular system & hematology
413 Veterinary science
Gastroenterology
HIGHLAND WHITE TERRIERS
0403 veterinary science
Pathogenesis
Idiopathic pulmonary fibrosis
0302 clinical medicine
Dog Diseases
Respiratory system
GENE-EXPRESSION
medicine.diagnostic_test
Interstitial lung disease
04 agricultural and veterinary sciences
Standard Articles
APOPTOSIS
3. Good health
medicine.anatomical_structure
Matrix Metalloproteinase 9
Matrix Metalloproteinase 7
Respiratory
Matrix Metalloproteinase 2
Bronchoalveolar Lavage Fluid
MMP-7
medicine.medical_specialty
040301 veterinary sciences
canine
BETA
lung
03 medical and health sciences
Dogs
Internal medicine
medicine
Animals
Clinical significance
Lung
General Veterinary
business.industry
MORTALITY
MATRIX-METALLOPROTEINASE-9
medicine.disease
Idiopathic Pulmonary Fibrosis
Cross-Sectional Studies
Bronchoalveolar lavage
SMALL ANIMAL
business
gelatinases
Zdroj: Journal of Veterinary Internal Medicine
ISSN: 1939-1676
0891-6640
Popis: Background Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, interstitial lung disease that mainly affects West Highland white terriers (WHWTs) and is characterized by excessive deposition of extracellular matrix (ECM) in the lung. Matrix metalloproteinases (MMPs) participate in remodeling of ECM. Objectives To compare metalloproteinase-2, -7 and -9 activities in blood or bronchoalveolar lavage fluid (BALF) samples or both of CIPF WHWTs with healthy WHWTs, healthy dogs of other breeds, and dogs with other lung diseases and determine if these MMPs could be used as diagnostic and prognostic markers for CIPF. Animals Forty-four CIPF WHWTs, 24 dogs with chronic bronchitis (CB), 17 with eosinophilic bronchopneumopathy (EBP), 10 with bacterial pneumonia, 39 healthy WHWTs, and 35 healthy dogs of other breeds. Methods Cross-sectional observational study. Pro-MMP and active MMP activities were analyzed by zymography. Results In serum, significantly higher (P
Databáze: OpenAIRE
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