A clinicobiochemical evaluation of curcumin as gel and as buccal mucoadhesive patches in the management of oral submucous fibrosis
| Autor: | Usha Va, Rajeshwari G. Annigeri, Aditi Chandrashekar, J. Thimmasetty |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Curcumin Oral Submucous Fibrosis Gastroenterology Group B Pathology and Forensic Medicine 03 medical and health sciences Curcumin Gel chemistry.chemical_compound 0302 clinical medicine Internal medicine Healthy volunteers medicine Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) business.industry 030206 dentistry Buccal administration medicine.disease Mouth opening Oral submucous fibrosis chemistry 030220 oncology & carcinogenesis Surgery Oral Surgery business After treatment |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 131:428-434 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2020.12.020 |
| Popis: | Objective The objective of this study was to evaluate and compare the efficacy of topical curcumin gel and buccal mucoadhesive patches in the management of oral submucous fibrosis (OSMF). Study Design Forty patients clinically diagnosed with OSMF were randomly divided into 2 groups. Group A received curcumin gel and group B received curcumin mucoadhesive patches, to be used twice daily for 8 weeks. Evaluation was done every 2 weeks. Serum lactate dehydrogenase (LDH) levels were measured before and after treatment and also in 20 healthy controls. Results A 100% reduction in burning sensation was observed in all 40 patients at the end of 4 weeks. Mouth opening improved by 5.45 ± 1.64 mm in group A and 5.9 ± 2.00 mm in group B. Pretreatment LDH was 359.72 ± 77.02 IU/L in patients with OSMF, which was significantly higher than that in healthy volunteers (173.2 ± 46.20 IU/L). In group A, LDH values reduced from 341.85 ± 71 IU/L to 264.95 ± 65.09 IU/L and in group B, values reduced from 377.6 ± 79.76 IU/L to 286.15 ± 72.95 IU/L after treatment. Conclusion Curcumin gel and mucoadhesive patches were effective in improving mouth opening and reducing burning sensation in patients with OSMF. They can therefore be considered as safe, noninvasive modalities for treatment of OSMF. |
| Databáze: | OpenAIRE |
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