Effects of an H3R antagonist on the animal model of autism induced by prenatal exposure to valproic acid
Autor: | Gustavo Della-Flora Nunes, Rudimar dos Santos Riesgo, Victorio Bambini-Junior, Gabriela Mueller de Melo, Carmem Gottfried, Kamila Castro, Diego Baronio, Taylor Gonchoroski |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
Histamine Antagonists lcsh:Medicine Pharmacology Marble burying Antagonistas dos receptores histamínicos H3 Mice Histamine receptor Transtorno do espectro autista Pregnancy Ciproxifan Animals Receptors Histamine H3 Medicine Autistic Disorder lcsh:Science Psychiatry H160 Valproic Acid Multidisciplinary Behavior Animal Ácido valpróico business.industry lcsh:R Imidazoles Antagonist medicine.disease Disease Models Animal Nociception Autism spectrum disorder Prenatal Exposure Delayed Effects Autism lcsh:Q Female lipids (amino acids peptides and proteins) business Research Article medicine.drug |
Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS PLoS ONE PLoS ONE, Vol 10, Iss 1, p e0116363 (2015) |
ISSN: | 1932-6203 |
Popis: | Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders primarily characterized by impaired social interaction and communication, and by restricted repetitive behaviors and interests. Ligands of histamine receptor 3 (H3R) are considered potential therapeutic agents for the treatment of different brain disorders and cognitive impairments. Considering this, the aim of the present study is to evaluate the actions of ciproxifan (CPX), an H3R antagonist, on the animal model of autism induced by prenatal exposure to valproic acid (VPA). Swiss mice were prenatally exposed to VPA on embryonic day 11 and assessed for social behavior, nociceptive threshold and repetitive behavior at 50 days of life. The treatment with CPX (3 mg/kg) or saline was administered 30 minutes before each behavioral test. The VPA group presented lower sociability index compared to VPA animals that were treated with CPX. Compared to the Control group, VPA animals presented a significantly higher nociceptive threshold, and treatment with CPX was not able to modify this parameter. In the marble burying test, the number of marbles buried by VPA animals was consistent with markedly repetitive behavior. VPA animals that received CPX buried a reduced amount of marbles. In summary, we report that an acute dose of CPX is able to attenuate sociability deficits and stereotypies present in the VPA model of autism. Our findings have the potential to help the investigations of both the molecular underpinnings of ASD and of possible treatments to ameliorate the ASD symptomatology, although more research is still necessary to corroborate and expand this initial data. |
Databáze: | OpenAIRE |
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