Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache

Autor: Supang Maneesri le Grand, Prangtip Potewiratnanond, Anan Srikiatkhachorn, Weera Supronsinchai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Nociception
medicine.medical_specialty
Migraine Disorders
Action Potentials
Trigeminal Nuclei
lcsh:RC321-571
Random Allocation
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Nitroglycerin
0302 clinical medicine
Internal medicine
Headache Disorders
Secondary
Animals
Medicine
030212 general & internal medicine
Rats
Wistar
Extracellular recording
Microinjection
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Acetaminophen
Cerebral Cortex
Neurons
Nucleus raphe magnus
business.industry
General Neuroscience
lcsh:QP351-495
Trigeminal nucleus caudalis
medicine.disease
Disease Models
Animal
Endocrinology
Paracetamol
lcsh:Neurophysiology and neuropsychology
Migraine
Muscimol
chemistry
Cortical spreading depression
Brainstem
business
Raphe nuclei
Proto-Oncogene Proteins c-fos
030217 neurology & neurosurgery
Research Article
Zdroj: BMC Neuroscience, Vol 20, Iss 1, Pp 1-10 (2019)
BMC Neuroscience
ISSN: 1471-2202
DOI: 10.1186/s12868-019-0536-2
Popis: Background The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons. Derangement of the brainstem modulating system, especially raphe nuclei may contribute to this hyperexcitability. The present study aimed to investigate the involvement of the nucleus raphe magnus (NRM) in the development of cortical and trigeminal hyperexcitability in a rat model of MOH. Results Chronic treatment with acetaminophen increased the frequency of cortical spreading depression (CSD) and the number of c-Fos-immunoreactive (Fos-IR) neurons in the trigeminal nucleus caudalis (TNC). In the control group, muscimol microinjected into the NRM increased significantly the frequency of CSD-evoked direct current shift and Fos-IR neurons in the TNC. This facilitating effect was not found in rats with chronic acetaminophen exposure. In a model of migraine induced by intravenous systemic infusion of nitroglycerin (NTG), rats with chronic exposure to acetaminophen exhibited significantly more frequent neuronal firing in the TNC and greater Fos-IR than those without the acetaminophen treatment. Muscimol microinjection increased neuronal firing in the TNC in control rats, but not in acetaminophen-treated rats. The number of Fos-IR cells in TNC was not changed significantly. Conclusion Chronic exposure to acetaminophen alters the function of the NRM contributing to cortical hyperexcitability and facilitating trigeminal nociception.
Databáze: OpenAIRE
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