Diffusion-weighted magnetic resonance imaging of treatment-associated changes in recurrent and residual medulloblastoma: preliminary observations in three children
| Autor: | Dorothee P. Auer, M. Wilke, S. Müller-Weihrich, M. I. Schubert |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Neoplasm Residual Adolescent medicine.medical_treatment Periventricular white matter Recurrent Tumor Lesion medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Cerebellar Neoplasms Medulloblastoma Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine medicine.disease Combined Modality Therapy Diffusion-Weighted Magnetic Resonance Imaging Radiation therapy Diffusion Magnetic Resonance Imaging Child Preschool Female Neoplasm Recurrence Local medicine.symptom Nuclear medicine business |
| Zdroj: | Acta Radiologica. 47:1100-1104 |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1080/02841850600990300 |
| Popis: | Purpose: To emphasize a possible role of magnetic resonance (MR) diffusion-weighted imaging (DWI) for lesion conspicuity and detection of treatment effects in children with medulloblastoma. Material and Methods: Three children with medulloblastoma (two residual and one recurrent) were examined repetitively by MR diffusion-weighted imaging. Regional assessment of the apparent diffusion coefficient (ADC) was done for tumorous lesions and periventricular white matter appearing normal on standard MR images. Results: All lesions were clearly visible on DWI. In the case of recurrent tumor, on one scan, DWI showed lesions that were not seen on contrast-enhanced MRI. Increase (41%) of ADC was seen in one lesion, which subsequently responded completely to treatment over 27 months' follow-up. Intermediate increases (23–26%) of ADC were found with partial therapy response in three lesions. In contrast, a decrease (-11%) of ADC in two lesions was seen with tumor progression. Conclusion: These observations may suggest a role for DWI in early detection of metastatic disease and treatment monitoring of medulloblastoma, warranting a formal study. |
| Databáze: | OpenAIRE |
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