Association between apolipoprotein B XbaI polymorphisms and coronary heart disease: A meta-analysis
| Autor: | Meng Luo, Lu Yang Chen, Jing Chang, Min Mao, Yang Liu, Yu-Hao Hu, Tian Tian Yang, Ya Yun Feng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system Apolipoprotein B Subgroup analysis Coronary Disease 030204 cardiovascular system & hematology Gastroenterology Risk Assessment 03 medical and health sciences 0302 clinical medicine Gene Frequency Internal medicine Genetic model Genotype medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Allele Polymorphism Polymorphism Genetic biology business.industry Publication bias Coronary heart disease Meta-analysis Heart Disease Risk Factors lcsh:RC666-701 Apolipoprotein B-100 biology.protein Gene polymorphism Cardiology and Cardiovascular Medicine business Research Article |
| Zdroj: | BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-12 (2020) BMC Cardiovascular Disorders |
| ISSN: | 1471-2261 |
| Popis: | Background To evaluate the association between apolipoprotein B gene polymorphism and coronary heart disease in some populations at home and abroad by means of meta-analysis. Methods Using the strict exclusion criteria for primary screening of the literature and applying the Hardy-Weinberg equilibrium to test the genetic balance of the selected literature. The corresponding models were selected according to the results of the heterogeneity test. The Begg’s test and Egger’s test were used to evaluate publication bias, and meta-analysis was performed using Stata 12.0. Results The study included twelve articles. In the literature, a total of 1596 patients with coronary heart disease and 1431 controls.Meta-analysis results showed no statistical value in the following three genetic models: allelic comparison (a vs A,P = 0.811,OR = 0.95, 95%CI = 0.62–1.46), recessive genetic models (aa vs Aa/AA, P = 0.86,OR = 0.94, 95%CI = 0.45–1.96), or dominant genetic models (aa/Aa vs AA, P = 0.73,OR = 0.92, 95%CI = 0.58–1.47). Subgroup analysis based on ethnicity showed allelic comparison (a vs A,P = 0.464,OR = 1.32, 95%CI = 0.63–2.78), recessive genetic models (aa vs Aa/AA, P = 0.422,OR = 1.52, 95%CI = 0.55–4.21), and dominant genetic models (aa/Aa vs AA, P = 0.551,OR = 1.26, 95%CI = 0.58–2.73) in Asians, allelic comparison (a vs A,P = 0.410,OR = 0.79, 95%CI = 0.45–1.39), recessive genetic models (aa vs Aa/AA, P = 0.041,OR = 0.75,95%CI = 0.57–0.99),dominant genetic models (aa/Aa vs AA, P = 0.385,OR = 0.75, 95%CI = 0.40–1.43) in Caucasian; Conclusion The ApoB(apolipoprotein B) XbaI locus is not a risk factor when it comes to the development of coronary heart disease in the domestic and international populations included in this paper. In Caucasians, people carrying the aa genotype may be less susceptible to CHD (coronary heart disease). The results of recessive genetic models have to take the effect of heterogeneity and sample sizes into account. Further research may require a larger and more rigorous research design. |
| Databáze: | OpenAIRE |
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