A Retrospective Observational Study: Is Absolute Lymphocyte Count a Prognostic Marker in COVID-19?
| Autor: | Zahra Maryam, Dana Safarova, Osei Kankam, Steve Moran, Umesh Dashora, O. A. Makanjuola, Viktoriya Clarke, Kamal Lawrence, Stefano Berliti, Reem Eldebri, Andreia Esteves Morete, Maaryah J Zafar, Bipin Pun, William A O'Neill, Bianca A Lazau, Simon Merritt, Saba Alam, Gjulio Ciroi, Mariya Farooq, Hesam A Nooredinvand, Tila Muhammad, Muhammad Shahbaz, Nadiyah Zafar, Lucinda Barry, Amr Elyasaky, Mark Whitehead, Ellie M Giddings, Karuna Subba, Mohamed Abdelbagi, Jabeen Hsiao, Mansoor Zafar, Athanasios Nakos, Ratan Singh Randhawa, Manivannan Periasamy, Alisha Khanna, Johannes Hegner, Najam-Us-Saher Rizvi, Mangala Karkhanis, B. A. Adekunle, Oluwamayowa Ojofeitimi, Bao Khuu, Ubaid Ur Rehman, Mirej Patel, Frederic Cuison |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) alcohol-related liver disease Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Lymphocyte firth logistic regression models for mortality Internal medicine Statistical significance Internal Medicine lasso model medicine stata version 16 (statacorp texas) lymphocyte count business.industry General Engineering Retrospective cohort study Hematology treat as positive (tap) medicine.anatomical_structure covid-19 Epidemiology/Public Health severe acute respiratory syndrome coronavirus-2 (sars-cov-2) Cohort copd: chronic obstructive pulmonary disease Observational study business restricted cubic splines Cohort study |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.16554 |
| Popis: | Aim Our study aimed to find a correlation between low absolute lymphocyte count and COVID-19-related mortality. Methods This study followed a retrospective observational cohort design to analyze the data of patients who presented with symptoms and signs of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at the Conquest Hospital and Eastbourne District General Hospital in East Sussex, United Kingdom, between February 10, 2020 and May 1, 2020, retrospectively. Survival and mortality for the first 30 days and comorbidities were analyzed for all patients who were tested for COVID-19 irrespective of swab results and had blood lymphocyte levels taken at the time of their visit to the ED and their data were analyzed for statistical significance. Results A total of 1226 patients had SARS-CoV-2 RNA identification swabs taken between February 10, 2020 and May 1, 2020. A cohort of 742 patients of these patients tested for COVID-19 also had blood lymphocyte levels measured. Overall, the lymphocyte count did not differ significantly between patients suspected to have COVID-19 infection with either positive or negative COVID-19 swab results. The lymphocyte count, however, was significantly lower in those who died from COVID-19 (p < 0.001) but when comorbidities were analyzed, we found an association between an increased number of comorbidities and a significantly decreased lymphocyte count. Conclusion Once adjusted for comorbidities, the lymphocyte count had no association with COVID-19 infection and mortality. |
| Databáze: | OpenAIRE |
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