Association of UGT2B7 polymorphisms with risk of induced liver injury by anti-tuberculosis drugs in Chinese Han

Autor: Jing-Can Wu, Guiyi Ji, Miaomiao Zhang, Guo Chen, Mei Feng, Jian-Qing He, Qianqian Liu, Shouquan Wu, Yu Wang
Rok vydání: 2017
Předmět:
uridine diphosphate glucuronyl transferase 2B7
Adult
Male
Risk
0301 basic medicine
medicine.medical_specialty
Tuberculosis
Immunology
Antitubercular Agents
Polymorphism
Single Nucleotide
Gastroenterology
polymorphism
Liver disorder
Young Adult
03 medical and health sciences
0302 clinical medicine
Asian People
Internal medicine
Isoniazid
medicine
Humans
Immunology and Allergy
Genetic Predisposition to Disease
Glucuronosyltransferase
Letters to the Editor
Prospective cohort study
Tuberculosis
Pulmonary
Ethambutol
Pharmacology
business.industry
Confounding
anti-tuberculosis drug-induced liver injury
Middle Aged
Pyrazinamide
medicine.disease
Genotype frequency
UGT2B7
030104 developmental biology
tuberculosis
030220 oncology & carcinogenesis
Drug Therapy
Combination
Female
Chemical and Drug Induced Liver Injury
Rifampin
business
medicine.drug
Zdroj: International Journal of Immunopathology and Pharmacology
ISSN: 2058-7384
Popis: Anti-tuberculosis drug-induced liver injury (ATLI) is common during the treatment of tuberculosis (TB). As an important enzyme in the metabolism of many drugs, UGT2B7 (uridine diphosphate glucuronyl transferase 2B7) was associated with drug-induced liver disorder. This study investigated the association between the polymorphisms of UGT2B7 and ATLI in Chinese Han. Totally, 280 newly diagnosed TB patients had been followed up for 3 months after the prescription of anti-TB therapy. Tag-single-nucleotide polymorphism (tag-SNPs) (rs10028494 and rs7668282) were genotyped with the MassARRAY platform. The associations between tag-SNPs and ATLI risk were analyzed by logistic regression analysis adjusting for confounding factors. In this prospective study, 33 patients were lost to follow-up, and 24 patients were diagnosed with ATLI and considered as the case group. The remaining 223 subjects without ATLI were considered as the control group. No significant association was observed in allele and genotype frequencies of UGT2B7 between the two groups. This study is the first attempt to investigate the association of genetic polymorphisms of UGT2B7 with ATLI in Chinese Han. There is no significant association between UGT2B7 polymorphisms and ATLI in Chinese Han.
Databáze: OpenAIRE
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