Prevention of heterotopic ossification in high-risk patients with total hip arthroplasty: the experience of a combined therapeutic protocol
| Autor: | Vasiliki Papathanasopoulou, Pericles Tsekeris, Theodore H. Xenakis, Kosmas S. Stafilas, Pitouli Ej, Emilios E. Pakos |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Arthroplasty Replacement Hip Indomethacin Arthritis medicine Humans Orthopedics and Sports Medicine Letter to the Editor Aged Aged 80 and over Original Paper Chi-Square Distribution Ossification business.industry Incidence (epidemiology) Ossification Heterotopic Anti-Inflammatory Agents Non-Steroidal Acetabular fracture Radiotherapy Dosage Middle Aged medicine.disease Arthroplasty Combined Modality Therapy Surgery Radiation therapy Radiography Treatment Outcome Orthopedic surgery Heterotopic ossification Female medicine.symptom business |
| Zdroj: | International orthopaedics. 30(2) |
| ISSN: | 0341-2695 |
| Popis: | The combination of radiotherapy and indomethacin for the prevention of heterotopic ossification (HO) in high-risk patients undergoing total hip arthroplasty (THA) has not been reported. The aim of the present study was to present the experience of our department with this combined therapeutic protocol. Fifty-four patients who underwent THA received a single dose of 7 Gy of postoperative radiotherapy and 75 mg of indomethacin for 15 days. Patients were analyzed for clinical and radiographical evidence of HO development at 1 year postoperatively. The overall radiographical incidence of HO was 20.4% (95% CI 10.6–33.5%), while only 1 patient with clinically significant HO was seen. Patients with secondary arthritis due to congenital hip disease had a statistically significantly higher incidence of HO compared with those with osteoarthrosis. The clinical assessment with the Merle d’Aubigné score showed that patients with radiographic documentation of HO had a lower mean score compared with those with no evidence of HO. No treatment-related side effects were seen. Combined radiotherapy and indomethacin was effective in preventing heterotopic ossification after total hip arthroplasty. The evaluation of this efficacy compared with radiotherapy or NSAIDs alone should be the future target of larger randomized designs. |
| Databáze: | OpenAIRE |
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