p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
| Autor: | Exequiel Barrera, Fernando Chirdo, Sergio Pantano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Models Molecular lcsh:Immunologic diseases. Allergy Inflammasomes Protein Conformation Biología Immunology Apoptosis Mice Transgenic Gliadin Mice Structure-Activity Relationship Intestine Small NLR Family Pyrin Domain-Containing 3 Protein Immunology and Allergy Animals Amino Acid Sequence Intestinal Mucosa coarse grained (CG) General Commentary Caspase 1 Peptide Fragments Disease Models Animal gliadin peptides Disease Susceptibility simulations Protein Multimerization sirah force field Peptides p31-43 lcsh:RC581-607 celiac disease |
| Zdroj: | Frontiers in Immunology, Vol 10 (2019) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| Popis: | In our recent publication p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine” (1) we showed by a combination of experimental and simulation techniques that the peptide p31-43 Gliadin has an intrinsic propensity to form oligomers, which trigger the NLRP3 inflammasome, resulting in intestinal inflammation and pathology. In particular, molecular simulations performed with the SIRAH force field (2), showed that isolated p31-43 peptides exhibit a broad conformational dynamic with some PPII component, mostly related to the presence of Pro36 and Pro42. Simulation of multiple replicas showed a spontaneous tendency to aggregation with a concomitant increase in the PPII content for Pro38 and Pro 39. Comentario al artículo p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestinepor Gómez Castro, M. F., Miculán, E., Herrera, M. G., Ruera, C., Perez, F., Prieto, E. D., et al. (2019). Front. Immunol. 10:31. doi: 10.3389/fimmu.2019.00031 Instituto de Estudios Inmunológicos y Fisiopatológicos |
| Databáze: | OpenAIRE |
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