Docosahexaenoic acid triglyceride-based microemulsions with an added dendrimer – Structural considerations
| Autor: | Nissim Garti, Roy E. Hoffman, Abraham Aserin, Nina Lidich, M. Francesca Ottaviani |
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| Rok vydání: | 2016 |
| Předmět: |
Dendrimers
Docosahexaenoic Acids Surface Properties 02 engineering and technology Polypropylenes 010402 general chemistry 01 natural sciences Propyleneimine Biomaterials Microviscosity Surface-Active Agents chemistry.chemical_compound Colloid and Surface Chemistry Dendrimer Organic chemistry Microemulsion Triglycerides Drug Carriers Viscosity Chemistry Water Permeation 021001 nanoscience & nanotechnology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Dilution Membrane Solubility Chemical engineering Emulsions 0210 nano-technology Drug carrier Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Journal of Colloid and Interface Science. 483:374-384 |
| ISSN: | 0021-9797 |
| DOI: | 10.1016/j.jcis.2016.08.036 |
| Popis: | Omega fatty acids, mainly the triglyceride of docosahexaenoic acid (TG-DHA), are considered important nutraceuticals. These compounds are water-insoluble and their transport across membranes depends on their carriers. Dendrimers are known as drug carriers across cell membranes and also as permeation enhancers. The solubilization of TG-DHA and dendrimer into a microemulsion (ME) system serving as a carrier could be used for a targeted delivery in the future. The interactions between TG-DHA and second generation poly(propyleneimine) dendrimers (PPI-G2) and their effect on structural transitions of ME were explored along the water dilution line using electron paramagnetic resonance and pulsed-gradient spin-echo NMR along with other analytical techniques. The microviscosity, order parameter, and micropolarity of all studied systems decrease upon water dilution. Incorporation of TG-DHA reduces the microviscosity, order, and micropolarity, whereas PPI-G2 leads to an increase in these parameters. The effect of PPI-G2 is more pronounced at relative high contents (1 and 5wt%) where PPI-G2 interacts with the hydrophilic headgroups of the surfactants. In the macroscale, the effects of TG-DHA and PPI-G2 differ mostly in the bicontinuous region, where macroviscosity increases upon TG-DHA incorporation and decreases upon solubilization of 5wt% PPI-G2. From DSC measurements it was concluded that in the presence of TG-DHA the PPI-G2 is intercalated easily at the interface. |
| Databáze: | OpenAIRE |
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