Monocyte Chemoattractant Protein 1 Is Correlated With Glycemic Control and Peripheral Arterial Disease in Type 2 Diabetic Patients With Metabolic Syndrome
| Autor: | Christos Antonoglou, Konstantinos Papatheodorou, E. Maltezos, Nikolaos Papanas, T. Gioka, D. Glaros, Dimitrios Papazoglou |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Group A Group B Pathogenesis Peripheral Arterial Disease Risk Factors Internal medicine Diabetes mellitus medicine Humans Ankle Brachial Index Chemokine CCL2 Aged Glycemic Glycated Hemoglobin Metabolic Syndrome business.industry Type 2 Diabetes Mellitus Middle Aged medicine.disease Peripheral Endocrinology Diabetes Mellitus Type 2 Hyperglycemia Female Metabolic syndrome Cardiology and Cardiovascular Medicine business |
| Zdroj: | Angiology. 64:223-229 |
| ISSN: | 1940-1574 0003-3197 |
| Popis: | We evaluated the serum levels of monocyte chemoattractant protein 1 (MCP-1) and their association with peripheral arterial disease (PAD) in 199 patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome ([MetS], group A) in comparison with 109 healthy controls (group B). In group A, MCP-1 levels were significantly ( P < .001) higher than group B and exhibited a positive correlation with HbA1c ( P < .001) and a negative correlation with ankle–brachial index ( P < .001). In the same group, patients with PAD had significantly higher MCP-1 levels compared with those without PAD ( P < .001). In conclusion, T2DM patients with MetS exhibit higher serum MCP-1 levels. The latter is associated with worse glycemic control and PAD. These results suggest a potential contributory role for MCP-1 in the pathogenesis of PAD in the presence of hyperglycemia and MetS in T2DM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|