Changes of Left and Right Ventricle Mechanics and Function in Patients with End-Stage Renal Disease Undergoing Haemodialysis
| Autor: | Rūta Ereminienė, Eglė Tamulėnaitė, Edita Žiginskienė, Rūta Žvirblytė, Eglė Ereminienė |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Medicine (General) cardiac mechanics haemodialysis speckle-tracking echocardiography Kidney failure chronic complications Renal dialysis Ventricular dysfunction left Ventricular dysfunction right Echocardiography methods Heart Ventricles Ventricular Dysfunction Right 030232 urology & nephrology Diastole Renal function Speckle tracking echocardiography 030204 cardiovascular system & hematology urologic and male genital diseases Statistics Nonparametric Article End stage renal disease 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine R5-920 Renal Dialysis medicine Humans Aged Retrospective Studies Body surface area Ejection fraction business.industry Lithuania General Medicine Mechanics Middle Aged medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Ventricle Kidney Failure Chronic 616.12-02:616.61 [udc] Female Hypertrophy Left Ventricular business Kidney disease |
| Zdroj: | Medicina; Volume 54; Issue 5; Pages: 87 Medicina, Vol 54, Iss 5, p 87 (2018) Medicina Medicina, Basel : MDPI, 2018, vol. 54, no. 5, 87, p. 1-10 Volume 54 Issue 5 |
| ISSN: | 1648-9144 1010-660X |
| DOI: | 10.3390/medicina54050087 |
| Popis: | Background and objectives: Chronic kidney disease (CKD) increases the risk of cardiovascular diseases even in its early stages and is associated with structural and functional cardiac abnormalities. The aim of this study was to use speckle-tracking echocardiography (STE) to evaluate left and right ventricle mechanics and function, markers of subclinical dysfunction in patients with end-stage renal disease (ESRD) undergoing haemodialysis. Methods: Patients with ESRD undergoing regular haemodialysis and with preserved left ventricle (LV) ejection fraction (EF) (n = 38) were enrolled in this retrospective study. The control group consisted of 32 age-matched persons with normal kidney function (glomerular filtration rate (GFR) > 90 mL/min/1.73 m2 according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)). Conventional 2D echocardiography and STE were performed in all patients. Results: 70 individuals, 31 (44.29%) males and 39 (55.71%) females, were included in the study. There were no significant differences in age, sex and body surface area between the groups. LV end diastolic diameter did not differ between the groups, while LV myocardial mass index was higher in the group of patients on haemodialysis (111.64 ± 27.99 versus 84.21 ± 16.99, p < 0.001) and LV diastolic dysfunction (LVDD) was found in 31 (81.6%) patients of this group. LV global longitudinal strain (GLS) (&minus 22.43 ± 2.71 versus &minus 24.73 ± 2.03, p < 0.001) and LV global circumferential strain (GCS) at the mitral valve and papillary muscles levels (&minus 18.73 ± 3.49 versus &minus 21.67 ± 2.22, p < 0.001 &minus 18.64 ± 2.75 versus &minus 20.42 ± 2.38, p = 0.005, respectively) were significantly lower in haemodialysis group patients. The parameters of the right ventricle (RV) free wall longitudinal function including RV GLS (&minus 22.63 ± 3.04 versus &minus 25.45 ± 2.48, p < 0.001), were reduced in haemodialysis patients compared with the controls. However, RV fractional area change (FAC) did not differ between the groups (p = 0.19). Conclusion: Patients with ESRD and preserved LV ejection fraction undergoing haemodialysis had a higher prevalence of LVDD and impaired LV longitudinal and circumferential deformation indices, as well as reduced RV longitudinal function and deformation parameters compared with the age-matched healthy controls. STE helps to detect subclinical LV and RV dysfunction in chronic haemodialysis patients. |
| Databáze: | OpenAIRE |
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