Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery
| Autor: | Long Giang Bach, Dai Hai Nguyen, Diem-Huong Nguyen Tran, Thai Thanh Hoang Thi, Duy Chinh Nguyen, Ki Dong Park, Hieu Vu-Quang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Iron oxide lcsh:RS1-441 Pharmaceutical Science Nanoparticle 02 engineering and technology Poloxamer heparin 010402 general chemistry 01 natural sciences doxorubicin Article lcsh:Pharmacy and materia medica chemistry.chemical_compound Copolymer core-shell structure MTT assay iron oxide nanoparticles 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences chemistry Chemical engineering Surface modification 0210 nano-technology surface modification Iron oxide nanoparticles |
| Zdroj: | Pharmaceutics Volume 11 Issue 3 Pharmaceutics, Vol 11, Iss 3, p 120 (2019) |
| ISSN: | 1999-4923 |
| Popis: | Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment. |
| Databáze: | OpenAIRE |
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