Reduced risk of distant recurrence after adjuvant chemotherapy in patients with stage III colon cancer aged 75 years or older
| Autor: | I. H. J. T. de Hingh, S.H. Goey, O. J. L. Loosveld, G.J.M. Creemers, F.N. van Erning, Valery E.P.P. Lemmens |
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| Přispěvatelé: | Medical Oncology, Public Health |
| Rok vydání: | 2013 |
| Předmět: |
Male
Oncology Reduced risk medicine.medical_specialty Colorectal cancer Adjuvant chemotherapy Gastroenterology SDG 3 - Good Health and Well-being Recurrence Risk Factors Internal medicine medicine Humans Aged Neoplasm Staging Netherlands Proportional Hazards Models Aged 80 and over business.industry Hazard ratio Age Factors Hematology medicine.disease Confidence interval Stage III Colon Cancer Treatment Outcome Chemotherapy Adjuvant Colonic Neoplasms Propensity score matching Population study Female business |
| Zdroj: | Annals of Oncology, 24(11), 2839-2844. Elsevier Ltd. |
| ISSN: | 1569-8041 0923-7534 |
| Popis: | Little is known about the effects of adjuvant chemotherapy on the risk of distant recurrence in elderly with stage III colon cancer, treated in daily practice.One thousand two hundred and ninety-one stage III colon cancer patients diagnosed in the southern Netherlands between 2003 and 2008 were included. Propensity score matching was applied to create a subsample to reduce bias caused by differences between patients receiving adjuvant chemotherapy and patients not receiving adjuvant chemotherapy. For both the total study population and the propensity score matched sample, Cox regression analysis was used to discriminate independent risk factors for distant recurrence.Adjuvant chemotherapy (CT) was correlated with a reduced risk of distant recurrence in both the total study population [hazard ratio (HR) CT versus nCT 0.55, 95% confidence interval (CI) 0.42-0.70] and in the propensity score matched sample (HR CT versus nCT 0.46, 95% CI 0.33-0.63). In separate analyses for patients aged75 and ≥75 years, the effect of adjuvant chemotherapy on the risk of distant recurrence remained comparable for both age groups (HR CT versus nCT 0.50, 95% CI 0.37-0.68 and 0.57, 95% CI 0.36-0.90, respectively).Distant recurrence risks at higher age definitely warrant consideration of adjuvant chemotherapy for elderly stage III colon cancer patients. This decision should be based on a multidisciplinary and functional assessment of the patient, not on age. |
| Databáze: | OpenAIRE |
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