Nontoxic embolic liquids for treatment of arteriovenous malformations
| Autor: | Yoshito Ikada, Kenji Sampei, N. Morikawa, Nobuyuki Sakaki, Hiroo Iwata, Kiyoshi Kazekawa, Tetsuro Shimozuru, Shojiro Matsuda |
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| Rok vydání: | 1997 |
| Předmět: |
Intracranial Arteriovenous Malformations
medicine.medical_specialty Cytotoxicity test medicine.medical_treatment Biomedical Engineering Biocompatible Materials Brain tissue Cell Line law.invention Arteriovenous Malformations Biomaterials Mice law medicine Animals Humans Methylmethacrylates Cyanoacrylates Embolization Polyhydroxyethyl Methacrylate medicine.diagnostic_test business.industry Brain Interventional radiology Arteriovenous malformation medicine.disease Embolization Therapeutic Surgery Radiography Catheter Cyanoacrylate Rabbits Congenital disease business |
| Zdroj: | Journal of Biomedical Materials Research. 38:79-86 |
| ISSN: | 1097-4636 0021-9304 |
| DOI: | 10.1002/(sici)1097-4636(199722)38:2<79::aid-jbm1>3.0.co;2-d |
| Popis: | Interventional radiology is becoming one of the standard treatments of arteriovenous malformation (AVM). Cyanoacrylate derivatives and polymer solutions are widely used to occlude the AVM nidus by their injection through a catheter, but they are far from satisfactory embolic liquids. For instance, cyanoacrylate derivatives sometimes glue the catheter to the artery, resulting in serious complications; in addition, the organic solvents used to dissolve polymers cause damage to the surrounding brain tissue of the AVM. Therefore, we attempted to develop embolic liquids by dissolving poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) in Iopamiron with an addition of a small amount of ethyl alcohol. This new embolic liquid is not cytotoxic and is easily injected into the AVM through a thin, long catheter to effectively occlude the AVM. |
| Databáze: | OpenAIRE |
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