Plasma phylloquinone, menaquinone-4 and menaquinone-7 levels and coronary artery calcification
| Autor: | Atsushi Shioi, Toshio Okano, T. Kakuta, Kengo Tanabe, M. Hatori, Sho Torii, Y Ikari |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Vitamin
t-ucMGP total circulating uncarboxylated matrix Gla protein medicine.medical_specialty Vitamin K MGP matrix Gla protein Endocrinology Diabetes and Metabolism ucOC uncarboxylated osteocalcin Population Osteocalcin Parathyroid hormone 030209 endocrinology & metabolism BAP bone-specific alkaline phosphatase Coronary artery calcification 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Osteoprotegerin N-terminal telopeptide Internal medicine Matrix gla protein CAC coronary artery calcification Medicine PIVKA-2 protein induced by vitamin K absence of antagonist-2 Matrix Gla protein PTH parathyroid hormone education education.field_of_study Creatinine Nutrition and Dietetics biology business.industry NTX N-terminal telopeptide MK menaquinone PK phylloquinone Endocrinology chemistry OPG osteoprotegerin biology.protein OC osteocalcin business PWV pulse wave velocity Food Science Research Article |
| Zdroj: | Journal of Nutritional Science |
| ISSN: | 2048-6790 |
| Popis: | Vitamin K is considered to be involved in the pathological mechanisms of coronary artery calcification (CAC). Correlation between CAC and plasma vitamin K levels was studied. A total of 103 patients, with at least one coronary risk factor, were studied. CAC was measured using 64-slice multislice computed tomography (MSCT) and divided into three groups: none (CAC score = 0; n 25), mild to moderate (0 n 52) and severe (CAC score > 400; n 26). Phylloquinone (PK) and menaquinone (MK)-4 and MK-7 were measured by HPLC-tandem MS. Mean age of patients was 64 (sd 13) years, of which 57 % were male. Median CAC score was 57·2. Median levels of PK, MK-4 and MK-7 were 1·33, 0 and 6·99 ng/ml, showing that MK-7 was the dominant vitamin K in this population. MK-7 showed a significant inverse correlation with uncarboxylated osteocalcin (ucOC, P = 0·014), protein induced by vitamin K absence of antagonist-2 (PIVKA-2, P = 0·013), intact parathyroid hormone (P = 0·007) and bone-specific alkaline phosphatase (P = 0·018). CAC showed an inverse correlation with total circulating uncarboxylated matrix Gla protein (t-ucMGP, P = 0·018) and Hb (P = 0·05), and a positive correlation with age (P P = 0·03), pulse wave velocity (P P |
| Databáze: | OpenAIRE |
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