Review on the Alteration of Gut Microbiota: The Role of HIV Infection and Old Age
| Autor: | Rui-Xue Leng, Bao-Zhu Li, Hai-Feng Pan, Tekle Airgecho Lobie, Akililu Alemu Ashuro, Dong-Qing Ye, Yin-Guang Fan |
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| Rok vydání: | 2020 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine Immunology Human immunodeficiency virus (HIV) HIV Infections Inflammation Gut flora medicine.disease_cause digestive system 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Virology medicine Humans 030212 general & internal medicine Review Articles Aged Gastrointestinal tract biology business.industry Probiotics Age Factors medicine.disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Infectious Diseases Viral replication Hiv patients Dysbiosis medicine.symptom business Immune activation |
| Zdroj: | AIDS Res Hum Retroviruses |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | Human immunodeficiency virus (HIV) infection results in gut microbiota alteration and this is associated with immune activation and chronic inflammation. The gastrointestinal tract is a primary site of viral replication and thus HIV-induced loss of T-helper (Th) cells in the gut causes impairments in intestinal barriers, resulting in disruptions in intestinal immunity and precipitating into gut dysbiosis. Here, we show that late HIV diagnosis can negatively affect the immunological, virological, and clinical prognosis of the patients with its higher implication at an older age. Further, the review indicates that antiretroviral therapy affects the gut microbiota. We discussed the use of probiotics and prebiotics that have been indicated to play a promising role in reversing gut microbiota alteration in HIV patients. Though there are several studies reported with regard to such alterations in gut microbiota regarding HIV infection, there is a need to provide comprehensive updates. It is, therefore, the objective of this review to present most recently available evidence on the alteration of gut microbiota among HIV patients. |
| Databáze: | OpenAIRE |
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