Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype
| Autor: | SJ Tyler, SH MacGowan, Skf Smith, Shelley J Allen, David Dawbarn, Ags Robertson, Gordon K. Wilcock, PH Holden |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Genotype Apolipoprotein E4 Disease Biology Hippocampus Choline O-Acetyltransferase Central nervous system disease Apolipoproteins E Degenerative disease Alzheimer Disease Reference Values Internal medicine medicine Humans Allele Alleles Aged Aged 80 and over General Neuroscience Brain Middle Aged medicine.disease Choline acetyltransferase Temporal Lobe Endocrinology Case-Control Studies Cholinergic Occipital Lobe Alzheimer's disease |
| Zdroj: | University of Bristol-PURE |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(97)00872-0 |
| Popis: | Apolipoprotein E (ApoE) is a potent risk factor for Alzheimer's disease. Since the loss of cholinergic function in Alzheimer's disease is known to occur at an early stage in the disease we have examined this function in normal subjects with an Apoepsilon4 allele to see if the deficit occurs in the absence of Alzheimer pathology or symptoms. We report that brain tissue obtained post-mortem from normal subjects and Alzheimer patients with an Apoepsilon4 allele has a lower cholinergic activity than tissue from those subjects without this allele. This has important significance for the interpretation of the cholinergic deficits found in Alzheimer's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect