Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes
| Autor: | Yuxiao Hong, Changping Li, Xue-Gang Xu, Shi-Ling Geng, Ting Xiao, Chao Ji, Ying Guo, Hong-Duo Chen, Wei Liu, John Z S Chen, Dapeng Li, Shi-Jun Shan, Huachen Wei |
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| Rok vydání: | 2011 |
| Předmět: |
Keratinocytes
Ultraviolet Rays aquaporin-3 Photoaging Cell Aquaporin Down-Regulation Human skin Antineoplastic Agents Biology Genetics medicine Humans Protein kinase C Cells Cultured Protein Kinase C Skin Aquaporin 3 Epidermis (botany) integumentary system Plant Extracts NF-kappa B General Medicine Articles medicine.disease Cell biology Kanglaite photoaging of skin medicine.anatomical_structure Apoptosis Immunology Coix Seeds Drugs Chinese Herbal |
| Zdroj: | International Journal of Molecular Medicine |
| ISSN: | 1791-244X |
| Popis: | Ultraviolet (UV) radiation plays an important role in the pathogenesis of skin photoaging. Depending on the wavelength of UV, the epidermis is affected primarily by UVB. One major characteristic of photoaging is the dehydration of the skin. Membrane-inserted water channels (aquaporins) are involved in this process. In this study we demonstrated that UVB radiation induced aquaporin-3 (AQP3) down-regulation in cultured human skin keratinocytes. Kanglaite is a mixture consisting of extractions of Coix Seed, which is an effective anti-neoplastic agent and can inhibit the activities of protein kinase C and NF-κB. We demonstrated that Kanglaite inhibited UVB-induced AQP3 down-regulation of cultured human skin keratinocytes. Our findings provide a potential new agent for anti-photoaging. The related molecular mechanisms remain to be further elucidated. |
| Databáze: | OpenAIRE |
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