Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples
| Autor: | Charlotte Martin, Sung Vo Duy, Jérôme Guitton, Béatrice Roy, Charles Dumontet, Jean-Yves Puy, Christian Périgaud, Isabelle Lefebvre-Tournier |
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| Přispěvatelé: | Organic Chemistry, Chemistry, WE Academic Unit |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Materials science
lcsh:Biotechnology Biomedical Engineering Pharmacology molecularly imprinted polymer LC-PDA Article Biomaterials chemistry.chemical_compound lcsh:TP248.13-248.65 medicine Solid phase extraction irinotecan lcsh:R5-920 Chromatography Molecularly imprinted polymer human serum Serum samples Organic media Irinotecan Polymerization Methacrylic acid chemistry lcsh:Medicine (General) Camptothecin medicine.drug |
| Zdroj: | Journal of Functional Biomaterials Journal of Functional Biomaterials; Volume 3; Issue 1; Pages: 131-142 Journal of Functional Biomaterials, Vol 3, Iss 1, Pp 131-142 (2012) |
| ISSN: | 2079-4983 |
| Popis: | A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine were selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 µmol•g−1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples. |
| Databáze: | OpenAIRE |
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