Association of B-type natriuretic peptide with coronary plaque subtypes detected by coronary computed tomography angiography in patients with stable chest pain

Autor: Yuhai Yang, Lei Zhao, Caiqin Li
Rok vydání: 2017
Předmět:
Male
Computed Tomography Angiography
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Logistic regression
Chest pain
Coronary artery disease
0302 clinical medicine
Risk Factors
Coronary plaque
Natriuretic Peptide
Brain
Odds Ratio
Prevalence
Natriuretic peptide
030212 general & internal medicine
Cardiac imaging
Coronary computed tomography angiography
Middle Aged
Prognosis
Coronary Vessels
Plaque
Atherosclerotic
cardiovascular system
Cardiology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
hormones
hormone substitutes
and hormone antagonists
circulatory and respiratory physiology
China
medicine.medical_specialty
medicine.drug_class
03 medical and health sciences
Double-Blind Method
Predictive Value of Tests
Internal medicine
Multidetector Computed Tomography
medicine
Humans
Radiology
Nuclear Medicine and imaging
In patient
Angina
Stable
cardiovascular diseases
Chi-Square Distribution
business.industry
medicine.disease
Cross-Sectional Studies
Logistic Models
Multivariate Analysis
Linear Models
business
human activities
Biomarkers
Zdroj: The International Journal of Cardiovascular Imaging. 33:1599-1606
ISSN: 1573-0743
1569-5794
Popis: Increased B-type natriuretic peptide (BNP) level has been suggested to improve clinical predictions of coronary events and all-cause mortality. We aimed to analyze the relationship between BNP levels and coronary plaque subtypes as detected by coronary computed tomography angiography (CCTA). 402 subjects undergoing CCTA were enrolled. The relationship between increased levels of BNP and plaque subtypes was tested using multivariable linear and logistic regression analysis. Plaques were categorized into subtypes of calcified, mixed and non-calcified. Coronary plaque was observed in 93 of 402 individuals. The participants were divided into three groups according to their serum BNP levels. Compared to those with low BNP level, subgroup with high BNP level had increased prevalence of all plaque types and mixed calcified arterial plaque (MCAP). Multivariable logistic regression analysis suggested increased BNP level predicted the MCAP. Multivariable logistic regression analysis between the presence of ≥2 plaques and BNP indicated that, subgroup with high BNP level was more likely to have MCAP than low BNP level. Our study suggests that increased BNP level is associated with MCAP detected by CCTA. Increased BNP level provides additional information about coronary artery disease in patients with stable chest pain detected by CCTA.
Databáze: OpenAIRE
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