Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence
| Autor: | Panagiota Klentrou, Amanda Kornel, Evangelia Tsiani, Danja J. Den Hartogh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
QH301-705.5 Osteoporosis myokines Adipose tissue Osteoclasts Review bone Catalysis Bone resorption clinical Inorganic Chemistry Internal medicine Myokine medicine Animals Homeostasis Humans Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Osteoblasts business.industry Organic Chemistry in vitro General Medicine medicine.disease osteoporosis Computer Science Applications Resorption Fibronectins Osteopenia Chemistry in vivo Endocrinology business irisin Increased bone formation osteocytes |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 9136, p 9136 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Bone is a highly dynamic tissue that is constantly adapting to micro-changes to facilitate movement. When the balance between bone building and resorption shifts more towards bone resorption, the result is reduced bone density and mineralization, as seen in osteoporosis or osteopenia. Current treatment strategies aimed to improve bone homeostasis and turnover are lacking in efficacy, resulting in the search for new preventative and nutraceutical treatment options. The myokine irisin, since its discovery in 2012, has been shown to play an important role in many tissues including muscle, adipose, and bone. Evidence indicate that irisin is associated with increased bone formation and decreased bone resorption, leading to reduced risk of osteoporosis in post-menopausal women. In addition, low serum irisin levels have been found in individuals with osteoporosis and osteopenia. Irisin targets key signaling proteins, promoting osteoblastogenesis and reducing osteoclastogenesis. The present review summarizes the existing evidence regarding the effects of irisin on bone homeostasis. |
| Databáze: | OpenAIRE |
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