Reduced nontarget embolization and increased targeted delivery with a reflux-control microcatheter in a swine model
| Autor: | Silvia Rizzitelli, Thomas Viel, Nir Holtzman, Fei Sun, Geert Maleux, Philippe Robert, Thierry de Baere, Claire Corot, Francois Montestruc, Gwenaelle Bazin, Michael Gabriel Tal, Pierre-Olivier Comby, Osnat Harbater, Eran Miller |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Catheters
Swine medicine.medical_treatment TRANSARTERIAL CHEMOEMBOLIZATION Non-target embolization Kidney 030218 nuclear medicine & medical imaging Microsphere 03 medical and health sciences Embolization 0302 clinical medicine Animal model Renal Artery MICROSPHERES TRANSCATHETER EMBOLIZATION HEPATOCELLULAR-CARCINOMA MANAGEMENT Medicine Animals Radiology Nuclear Medicine and imaging HEMOPTYSIS LIVER-CANCER Renal embolization Interventional radiology Science & Technology Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Radiology Nuclear Medicine & Medical Imaging Reflux General Medicine ARTERY EMBOLIZATION Embolization Therapeutic Microspheres EMBOLOTHERAPY Catheter Preclinical evaluation X-ray microtomography 030220 oncology & carcinogenesis Both kidneys Therapeutic business Nuclear medicine Life Sciences & Biomedicine ANTIREFLUX CATHETER |
| Popis: | PURPOSE: To evaluate the potential differences in non-target embolization and vessel microsphere filling of a reflux-control microcatheter (RCM) compared to a standard end-hole microcatheter (SEHM) in a swine model. MATERIALS AND METHODS: Radiopaque microspheres were injected with both RCM and SEHM (2.4-Fr and 2.7-Fr) in the kidneys of a preclinical swine model. Transarterial renal embolization procedures with RCM or SEHM were performed in both kidneys of 14 pigs. Renal arteries were selectively embolized with an automated injection protocol of radio-opaque microspheres. Ex-vivo X-ray microtomography images of the kidneys were utilized to evaluate the embolization by quantification of the deposition of injected microspheres in the target vs. the non-target area of injection. X-ray microtomography images were blindly analyzed by five interventional radiologists. The degree of vessel filling and the non-target embolization were quantified using a scale from 1 to 5 for each parameter. An analysis of variance was used to compare the paired scores. RESULTS: Total volumes of radio-opaque microspheres injected were similar for RCM (11.5±3.6 [SD] mL; range: 6-17mL) and SEHM (10.6±5.2 [SD] mL; range: 4-19mL) (P=0.38). The voxels enhanced ratio in the target (T) vs. non-target (NT) areas was greater with RCM (T=98.3% vs. NT=1.7%) than with SEHM (T=89% vs. NT=11%) but the difference was not significant (P=0.30). The total score blindly given by the five interventional radiologists was significantly different between RCM (12.3±2.1 [SD]; range: 6-15) and the standard catheter (11.3±2.5 [SD]; range: 4-15) (P=0.0073), with a significant decrease of non-target embolization for RCM (3.8±1.3 [SD]; range: 3.5-4.2) compared to SEHM (3.2±1.5 [SD]; range: 2.9-3.5) (P=0.014). CONCLUSION: In an animal model, RCM microcatheters reduce the risk of non-target embolization from 11% to 1.7%, increasing the delivery of microspheres of 98% to the target vessels, compared to SEHM microcatheters. ispartof: DIAGNOSTIC AND INTERVENTIONAL IMAGING vol:102 issue:10 pages:641-648 ispartof: location:France status: published |
| Databáze: | OpenAIRE |
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