Fructose metabolism and cardiac metabolic stress
Autor: | S. L. James, H. A. Ambalawanar, L.M.D. Delbridge, Kimberley M. Mellor, J. P. H. Neale, Marco Annandale, A. H. L. Chau, L. J. Daniels, Parisa Koutsifeli, X. Li |
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Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Mini Review RM1-950 030204 cardiovascular system & hematology Carbohydrate metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polyol pathway Internal medicine Diabetic cardiomyopathy medicine Pharmacology (medical) Glycolysis carbohydrate metabolism fructolysis Pharmacology Aldose reductase cardiac lipogenesis Fructose medicine.disease diabetic cardiomyopathy (DCM) 030104 developmental biology Endocrinology chemistry advanced glycation end – products Fructolysis Therapeutics. Pharmacology Phosphofructokinase |
Zdroj: | Frontiers in Pharmacology, Vol 12 (2021) Frontiers in Pharmacology |
Popis: | Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in diabetic patients, and cardiac production of fructose via the intracellular polyol pathway is upregulated. The question of whether direct myocardial fructose exposure and upregulated fructose metabolism have potential to induce cardiac fructose toxicity in metabolic stress settings arises. Unlike tightly-regulated glucose metabolism, fructose bypasses the rate-limiting glycolytic enzyme, phosphofructokinase, and proceeds through glycolysis in an unregulated manner. In vivo rodent studies have shown that high dietary fructose induces cardiac metabolic stress and functional disturbance. In vitro, studies have demonstrated that cardiomyocytes cultured in high fructose exhibit lipid accumulation, inflammation, hypertrophy and low viability. Intracellular fructose mediates post-translational modification of proteins, and this activity provides an important mechanistic pathway for fructose-related cardiomyocyte signaling and functional effect. Additionally, fructose has been shown to provide a fuel source for the stressed myocardium. Elucidating the mechanisms of fructose toxicity in the heart may have important implications for understanding cardiac pathology in metabolic stress settings. |
Databáze: | OpenAIRE |
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