Microwave Ablation for Lung Neoplasms: A Retrospective Analysis of Long-Term Results

Autor: Damian E. Dupuy, Terrance T. Healey, Bradford T. March, Grayson L. Baird
Rok vydání: 2016
Předmět:
Ablation Techniques
Male
medicine.medical_specialty
Lung Neoplasms
Time Factors
medicine.medical_treatment
Kaplan-Meier Estimate
Malignancy
Radiography
Interventional
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Risk Factors
Carcinoma
Non-Small-Cell Lung
Carcinoma
Odds Ratio
Medicine
Humans
Radiology
Nuclear Medicine and imaging
Microwaves
Aged
Retrospective Studies
Aged
80 and over
Academic Medical Centers
business.industry
Microwave ablation
Rhode Island
Solitary Pulmonary Nodule
Retrospective cohort study
Odds ratio
medicine.disease
Confidence interval
Surgery
Tumor Burden
Radiation therapy
Logistic Models
Treatment Outcome
030220 oncology & carcinogenesis
Female
Sarcoma
Neoplasm Recurrence
Local
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Tomography
X-Ray Computed
Zdroj: Journal of vascular and interventional radiology : JVIR. 28(2)
ISSN: 1535-7732
Popis: To determine the long-term safety and efficacy of microwave (MW) ablation in the treatment of lung tumors at a single academic medical center.Retrospective review was performed of 108 patients (42 female; mean age, 72.5 y ± 10.3 [standard deviation]) who underwent computed tomography (CT)-guided percutaneous MW ablation for a single lung malignancy. Eighty-two were primary non-small-cell lung cancers and 24 were metastatic tumors (9 colorectal carcinoma, 2 renal-cell carcinoma, 4 sarcoma, 2 lung, and 7 other). Mean maximum tumor diameter was 29.6 mm ± 17.2. Patient clinical and imaging data were reviewed. Statistical analysis was performed by Kaplan-Meier modeling and logistic regression.Odds of primary technical success were 11.1 times higher for tumors3 cm vs those3 cm (95% confidence interval [CI], 2.97-41.1; P = .0003). For every millimeter increase in original tumor maximal diameter (OMD), the odds of not attaining success increased by 7% (95% CI, 3%-10%; P = .0002). For every millimeter increase in OMD, the odds of complications increased by 3% (95% CI, 0.1%-5%; P = .04). Median time to tumor recurrence was 62 months (95% CI, 29, upper bound not reached; range, 0.2-96.6 mo). Recurrence rates were estimated at 22%, 36%, and 44% at 1, 2, and 3 years, respectively. Recurrence rates were estimated at 31% at 13 months for tumors3 cm and 17% for those3 cm. Complications included pneumothorax (32%), unplanned hospital admission (28%), pain (20%), infection (7%), and postablation syndrome (4%).This study further supports the safe and effective use of MW ablation for the treatment of lung tumors.
Databáze: OpenAIRE
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