Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver
| Autor: | Egle Machado de Almeida Siqueira, Marcela de Sá Barreto da Cunha, Sandra Fernandes Arruda, Adriana M. Fustinoni-Reis, Lívia Pimentel de Sant’Ana Dourado |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Glutathione reductase Arecaceae Protein oxidation medicine.disease_cause Antioxidants Lipid peroxidation Protein Carbonylation chemistry.chemical_compound Homeostasis oxidative stress Intestinal Mucosa Nutrition and Dietetics biology tucum-do-cerrado (Bactris setosa Mart.) Hamp Nfr2 Catalase Glutathione Up-Regulation Intestines Biochemistry Liver Food Fortified HAMP lcsh:Nutrition. Foods and food supply medicine.medical_specialty Iron lcsh:TX341-641 Article 03 medical and health sciences Hepcidins Internal medicine medicine Animals RNA Messenger Rats Wistar 030109 nutrition & dietetics Transferrin saturation Plant Extracts Diet 030104 developmental biology Endocrinology chemistry biology.protein Lipid Peroxidation Oxidative stress Spleen Food Science |
| Zdroj: | Nutrients; Volume 8; Issue 2; Pages: 38 Nutrients, Vol 8, Iss 2, p 38 (2016) Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu8020038 |
| Popis: | This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) diet, for 30 days. Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine. Tucum-do-cerrado consumption reduced spleen lipid and protein oxidation; mRNA levels of hepatic Hamp and Ftl, and increased serum antioxidant capacity and hepatic mRNA levels of Bmp6, Hmox1, Nqo1, and Nrf2. TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues. These results suggest that tucum-do-cerrado protects tissues against oxidative damage, by reducing iron availability in liver and consequently inhibiting liver Hamp expression. |
| Databáze: | OpenAIRE |
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