Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose
| Autor: | Thomas Gustafsson, Simon Gaisford, Abdul Basit, Dariush Nikjoo, Mohammed Elbadawi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fabrication
Materials science Drug Compounding Administration Oral Pharmaceutical Science 02 engineering and technology engineering.material 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems Hypromellose Derivatives 0302 clinical medicine Rheology Tensile Strength Ultimate tensile strength Pressure Technology Pharmaceutical Composite material Glucans Elastic modulus Dosage Forms chemistry.chemical_classification Viscosity Pullulan Polymer 021001 nanoscience & nanotechnology Elasticity Drug Liberation chemistry Printing Three-Dimensional Drug delivery engineering Biopolymer 0210 nano-technology |
| Zdroj: | International Journal of Pharmaceutics. 595:120197 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2021.120197 |
| Popis: | Oral films (OFs) continue to attract attention as drug delivery systems, particularly for pedatric and geriatric needs. However, immiscibility between different polymers limits the full potential of OFs from being explored. One example is pullulan (PUL), a novel biopolymer which often has to be blended with other polymers to reduce cost and alter its mechanical properties. In this study, the state-of-the-art in fabrication techniques, three-dimensional (3D) printing was used to produce hybrid film structures of PUL and hydroxypropyl methylcellulose (HPMC), which were loaded with caffeine as a model drug. 3D printing was used to control the spatial deposition of films. HPMC was found to increase the mean mechanical properties of PUL films, where the tensile strength, elastic modulus and elongation break increased from 8.9 to 14.5 MPa, 1.17 to 1.56 GPa and from 1.48% to 1.77%, respectively. In addition, the spatial orientation of the hybrid films was also explored to determine which orientation could maximize the mechanical properties of the hybrid films. The results revealed that 3D printing could modify the mechanical properties of PUL whilst circumventing the issues associated with immiscibility. |
| Databáze: | OpenAIRE |
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