HCAR1-Mediated l-Lactate Signaling Suppresses Microglial Phagocytosis

Autor:	Raneen Nicola, Ravit Madar, Eitan Okun
Rok vydání:	2022
Předmět:	Cellular and Molecular Neuroscience Phagocytosis Neurology Molecular Medicine Microglia Lactic Acid Receptors G-Protein-Coupled Signal Transduction
Zdroj:	NeuroMolecular Medicine. 24:399-404
ISSN:	1559-1174 1535-1084
Popis:	Microglia, the primary brain-resident immune cells, protect the brain from various harmful pathogens, insulting and maintaining its homeostasis by phagocytosing extracellular particles. How microglia are metabolically regulated by their microenvironment remains largely elusive. Here, we investigated how extracellular lactate, which is abundant in the brain and dynamically changes in pathological states, affects microglial phagocytotic ability. We show that L-lactate reduces microglia phagocytic capacity in a Hydroxycarboxylic Acid Receptor 1 but not Monocarboxylate transporter 1-dependent manner. Our findings point to a potential role for extracellular lactate in suppressing the phagocytic activity of microglial cells in homeostasis and inflammatory conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80820673b6750f956671da8f8439715f https://doi.org/10.1007/s12017-022-08710-5 Zobrazit plný text záznamu Full text from SpringerLink