Pd-Catalyzed Tandem Isomerization/Cyclization for the Synthesis of Aromatic Oxazaheterocycles and Pyrido[3,4-b]indoles

Autor:	Yan-Ning Niu, Linglong Ding, Xiao-Feng Xia
Rok vydání:	2021
Předmět:	Indoles Molecular Structure Tandem Chemistry Organic Chemistry Intramolecular cyclization Alkenes Medicinal chemistry Catalysis Isomerism Cyclization Rapid access Stereoselectivity Isomerization Palladium
Zdroj:	The Journal of Organic Chemistry. 86:10032-10042
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.1c00770
Popis:	An effient tandem process consisting of palladium-catalyzed double-bond isomerization of long-chain olefins and subsequent intramolecular cyclization promoted by B2(OH)2 for the synthesis of aromatic oxazaheterocycles is disclosed. This strategy can also provide rapid access to pyrido[3,4-b]indoles, trans-2-olefins, and eneamides bearing various functional groups with high regio- and stereoselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80811bfbd7513ac4bca710b843e3b0b1 https://doi.org/10.1021/acs.joc.1c00770 Zobrazit plný text záznamu