Decreased monoamine oxidase (MAO) activity and MAO-A expression as diagnostic indicators of human esophageal cancers

Autor:	Guojun Geng, Chengcai Yao, Jie Jiang, Bingye Yang, Haoxin Du, Zhen Jiang, Qiqing Zhang, Lihua Jin
Rok vydání:	2009
Předmět:	Adult Male Pathology medicine.medical_specialty Esophageal Neoplasms Monoamine oxidase Health Toxicology and Mutagenesis Clinical Biochemistry Down-Regulation Malignancy Biochemistry Biomarkers Tumor medicine Humans Monoamine Oxidase biology Esophageal disease Cancer Biological activity Middle Aged Esophageal cancer medicine.disease biology.protein Cancer research Female Cancer biomarkers Monoamine oxidase A
Zdroj:	Biomarkers. 14:624-629
ISSN:	1366-5804 1354-750X
DOI:	10.3109/13547500903207688
Popis:	Human esophageal cancer is a common occurring malignancy with high mortality rate partially due to lack of tools for early diagnosis. In this study, we have analysed tumour tissue from 50 cases of primary esophageal cancer. Our studies showed that the activity of monoamine oxidase (MAO) and the expression of MAO-A were strikingly decreased in the tumour tissues of 48 (96%) and 44 (88%) patients, respectively. These results suggest that the activity of MAO and the expression of MAO-A may be used as new diagnostic markers for esophageal cancers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807d72a4a057cb49348eb9e558d78bed https://doi.org/10.3109/13547500903207688 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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