The Effects of Soyferment-Tempeh on Lipid Profile, Retinol-Binding Protein 4 (RBP4), and Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression in Type 2 Diabetic Mice
| Autor: | Dian Setiawan Ghozali, Prasetyastuti Prasetyastuti |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment Pharmaceutical Science Pharmacy medicine.disease_cause chemistry.chemical_compound Pharmacy and materia medica Internal medicine Diabetes mellitus medicine Pharmacology (medical) Retinol binding protein 4 medicine.diagnostic_test biology Chemistry Isoflavones medicine.disease Metformin RS1-441 Endocrinology biology.protein soyferment-tempeh lipid profile atherogenic index retinol-binding protein 4 phosphoenol pyruvate carboxykinase Phosphoenolpyruvate carboxykinase Lipid profile Oxidative stress medicine.drug |
| Zdroj: | Indonesian Journal of Pharmacy, Pp 193-200 (2021) |
| ISSN: | 2338-9486 2338-9427 |
| DOI: | 10.22146/ijp.1354 |
| Popis: | Diabetes Type 2 can cause oxidative stress leading to the accumulation of reactive oxygen species. Soyferment-Tempeh, a fermented soybean product with aerobic and anaerobic R. oligosporus incubation has a high antioxidant content of isoflavones that can regulate oxidative stress in diabetes. In this study, we evaluate the effects of Soyferment-Tempeh on lipid profile, Retinol-Binding Protein 4 (RBP4), and Phosphoenolpyruvate Carboxykinase (PEPCK) gene expression in type 2 diabetic mice. A total of 30 mice with the age of eight weeks were divided into six groups as follows: A) nondiabetic, B) diabetic mice, C) diabetic mice with metformin, D), E), and F) diabetic mice with Soyferment-Tempeh doses of 10, 20, or 40mg/100g body weight (BW), respectively, were administered treatments orally by gavages. Blood was collected for assessment of blood glucose level, and lipid profile before and after 3 weeks of the administration. After sacrificing the mice, livers were used for RBP4 and PEPCK gene expression assessment. Supplementation with three different doses of Soyferment-Tempeh in streptozotocin-induced diabetic mice for 21 days significantly (p0.05). These results demonstrate that supplementation with Soyferment-Tempeh decreases blood glucose level, atherogenic index, improves lipid profile, and decreases RBP4. |
| Databáze: | OpenAIRE |
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