Tracking the establishment of local endemic populations of an emergent enteric pathogen
| Autor: | My Phan Vu Tra, Julian Parkhill, Nguyen Thi Nam Lien, Nguyen Manh Tien, Nicholas R. Thomson, Ha Vinh, Christopher M. Parry, Dong Wook Kim, Phat Voong Vinh, Stephen Baker, Cao Thu Thuy, Pham Van Minh, Pham Thi Ngoc Tuyet, Nguyen Thi Khanh Nhu, Nguyen Thi Thuy Ai, Bui Duc Phu, Nguyen Dong, Tran Thi Thu Nga, Nguyen Thanh Vinh, Nguyen Van Minh Hoang, Corinne N. Thompson, Tran Vu Thieu Nga, Hoang Le Phuc, Kathryn E. Holt, Duy Pham Thanh, James Campbell, Tran Tinh Hien, Tran Thi Ngoc Dung, Jeremy Farrar, Gordon Dougan |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Endemic Diseases
Population Molecular Sequence Data Shigella sonnei Human pathogen Genomics Biology Gatifloxacin Evolution Molecular Mutation Rate Ciprofloxacin Convergent evolution Humans education Child Phylogeny Dysentery Bacillary Genetics education.field_of_study Multidisciplinary Geography Microevolution Genetic Variation Infant Sequence Analysis DNA Biological Sciences Chromosomes Bacterial Anti-Bacterial Agents Fixation (population genetics) Vietnam Child Preschool Gene pool Genome Bacterial Fluoroquinolones |
| Zdroj: | Proceedings of the National Academy of Sciences |
| Popis: | Significance Shigella sonnei is a globally emerging agent of bacterial dysentery. Here, we use genomics to examine the microevolution of S. sonnei in Vietnam. We show that S. sonnei was introduced into Vietnam in the early 1980s, where it continued to evolve, spreading geographically to establish localized founder populations. The population in Ho Chi Minh City has undergone several localized clonal replacement events, during which a small number of microevolutionary changes have risen to dominance. These changes, induced by horizontal gene transfer and substitution mutations, confer high-level antimicrobial resistance and the ability to kill other gut bacteria. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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