Use of Anti-Craving Agents in Soldiers with Alcohol Dependence Syndrome

Autor:	PK Sharma, PL Narayana, Amita Gupta
Rok vydání:	2008
Předmět:	Topiramate medicine.medical_specialty business.industry Alcohol dependence syndrome Craving General Medicine Naltrexone Navy Acamprosate Pill behavior and behavior mechanisms medicine Original Article medicine.symptom Psychiatry business medicine.drug Coast guard
Zdroj:	Medical Journal Armed Forces India. 64:320-324
ISSN:	0377-1237
DOI:	10.1016/s0377-1237(08)80009-3
Popis:	In a search for an effective 'anti-alcohol pill', three modern anti-craving agents have been studied in alcoholics of Army/ DSC, Air Force, Navy and Coast Guard.129 patients of alcohol dependence syndrome were randomly assigned to three groups where topiramate, acamprosate and naltrexone were used as anti-craving agents in a year long prospective study. Of these 92 patients completed the study.Topiramate (76.3%) appears to be significantly more effective (p0.01) in sustaining abstinence, though naltrexone (57.7%) and acamprosate (60.70%) offer moderate relapse-prevention efficacy. Side effects of all the three agents have been mild, transient and self-limiting. We recommend a trial of topiramate, before invaliding out of any alcoholic soldier.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80781e7b107452b5b6139f4d1999ca17 https://doi.org/10.1016/s0377-1237(08)80009-3 Zobrazit plný text záznamu Full Text from ScienceDirect