Unusual Aspergillus species in patients with cystic fibrosis
| Autor: | Laurent Mely, Jean-Philippe Bouchara, Fran Ç Oise Symoens, Nicolas Degand, Hugues Beguin, Gerhard Haase, Marc Pihet, Jacqueline Carrère |
|---|---|
| Přispěvatelé: | Mycology [Brussels], Institut Scientifique de Santé Publique [Belgique] - Scientific Institute of Public Health [Belgium] (WIV-ISP), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Laboratoire de Parasitologie-Mycologie [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Hôpital Renée Sabran [CHU - HCL], Hospices Civils de Lyon (HCL) |
| Rok vydání: | 2010 |
| Předmět: |
Male
MESH: Sequence Analysis DNA Antifungal Agents Cystic Fibrosis MESH: Eurotiales / isolation & purification [SDV]Life Sciences [q-bio] Aspergillus lentulus MESH: Eurotiales / classification Cystic fibrosis MESH: Eurotiales / drug effects Amphotericin B Mycological Typing Techniques 0303 health sciences MESH: Microbial Sensitivity Tests Neosartorya pseudofischeri MESH: Eurotiales / genetics General Medicine MESH: Lung Diseases Fungal / microbiology Eurotiales 3. Good health medicine.drug_formulation_ingredient Infectious Diseases Aspergillus medicine.symptom medicine.drug Adult Adolescent Microbial Sensitivity Tests Biology MESH: Sputum / microbiology Microbiology 03 medical and health sciences MESH: Antifungal Agents / pharmacology Species Specificity MESH: Mycological Typing Techniques medicine airway colonization MESH: Species Specificity Humans 030304 developmental biology Voriconazole MESH: Adolescent MESH: Humans Lung Diseases Fungal 030306 microbiology MESH: Aspergillus / classification Sputum MESH: Adult Sequence Analysis DNA MESH: Aspergillus / drug effects biology.organism_classification medicine.disease MESH: Male Culture Media MESH: Aspergillus / genetics MESH: Aspergillus / isolation & purification MESH: Culture Media MESH: Pulmonary Aspergillosis / microbiology Pulmonary Aspergillosis MESH: Cystic Fibrosis / microbiology |
| Zdroj: | Medical Mycology Medical Mycology, Oxford University Press, 2010, 48 (O1), pp.S10-S16. ⟨10.3109/13693786.2010.501345⟩ |
| ISSN: | 1460-2709 1369-3786 1365-280X |
| DOI: | 10.3109/13693786.2010.501345⟩ |
| Popis: | International audience; Poorly sporulating Aspergillus isolates from patients with cystic fibrosis (CF) are generally identified in routine procedures as Aspergillus spp. In this study, we identified and characterized 11 isolates belonging to two unusual Aspergillus species of the section Fumigati (A. lentulus and Neosartorya pseudofischeri) recovered from four different patients. Aspergillus lentulus was found occasionally during a 10-year follow-up study of one CF patient colonized by A. fumigatus. Neosartorya pseudofischeri was isolated from three patients followed in different European hospitals. This species was recovered from two sputum samples of one patient, and from four successive samples of the two other patients, suggesting that it may be responsible for chronic colonization. Both species were isolated together with A. fumigatus. Isolates from both species did not grow at 50°C, and DNA sequence analysis, together with further morphological observations permitted identification at the species level. Growth at different temperatures and antifungal susceptibility were also investigated. All the isolates of N. pseudofischeri exhibited a very low susceptibility to voriconazole (VRZ) whereas a very low susceptibility to VRZ and amphotericin B was seen with the A. lentulus isolates. |
| Databáze: | OpenAIRE |
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