Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland
| Autor: | Gerard J. Graham, Kenneth Pallas, Kay Hewit, Torsten Stein, Gillian J. Wilson, Claire J. Cairney, Kit Ming Lee, Christopher A.H. Hansell |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
ACKR2 Chemokine medicine.medical_specialty Mouse Branching Mammary gland Regulator Mice Receptors CCR 03 medical and health sciences Chemokine receptor Mammary Glands Animal Cell Movement In vivo Internal medicine Morphogenesis medicine Lymphatic vessel Animals Lymphangiogenesis 10. No inequality Receptor Molecular Biology Lymphatic Vessels Mice Knockout biology Macrophages Embryo Mammalian Cell biology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Endocrinology biology.protein CCL28 Female Receptors Chemokine Chemokines Stromal Cells Research Article Developmental Biology |
| Zdroj: | Development (Cambridge, England) |
| ISSN: | 1477-9129 0950-1991 |
| Popis: | Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development. We demonstrate here that the developing mammary gland expresses high levels of inflammatory CC-chemokines, which are essential in vivo regulators of macrophage migration. We further demonstrate that the atypical chemokine receptor ACKR2, which scavenges inflammatory CC-chemokines, is differentially expressed during mammary gland development. We have previously shown that ACKR2 regulates macrophage dynamics during lymphatic vessel development. Here, we extend these observations to reveal a novel role for ACKR2 in regulating the postnatal development of the mammary gland. Specifically, we show that Ackr2−/− mice display precocious mammary gland development. This is associated with increased macrophage recruitment to the developing gland and increased density of the ductal epithelial network. These data demonstrate that ACKR2 is an important regulator of branching morphogenesis in diverse biological contexts and provide the first evidence of a role for chemokines and their receptors in postnatal development processes. Summary: Ackr2−/− mice display precocious mammary gland development as a result of impaired chemokine scavenging and increased macrophage recruitment to the mammary gland. |
| Databáze: | OpenAIRE |
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