Sex differences in late behavioral response to subcutaneous formalin injection in mice
| Autor: | Susan Jin Kim, Feng Wei, Ping Li, Amelita A. Calejesan, Min Zhuo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Formalin Test medicine.drug_class Ratón Injections Subcutaneous Pain Mice Internal medicine Noxious stimulus Animals Medicine Molecular Biology Pain Measurement Estrous cycle Sex Characteristics business.industry Local anesthetic General Neuroscience Mice Inbred C57BL Sexual dimorphism Endocrinology Nociception Female Neurology (clinical) business Developmental Biology Sex characteristics |
| Zdroj: | Brain Research. 829:185-189 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(99)01353-0 |
| Popis: | We investigated sex- or gender-dependent differences in nociception using the formalin test in mice. In addition to typical biphasic responses, a new, late phase (Phase 3) was observed. A local anesthetic QX-314 injected at the end of Phase 2 blocked Phase 3. Phase 3 in female mice was significantly greater than that in male mice regardless the stage of the estrus cycle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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