Direct Addition of Grignard Reagents to Aliphatic Carboxylic Acids Enabled by Bulky turbo ‐Organomagnesium Anilides

Autor:	Kilian Colas, A. Catarina V. D. Santos, Stefanie V. Kohlhepp, Abraham Mendoza
Rok vydání:	2022
Předmět:	Molecular Structure Organic Chemistry Carboxylic Acids Organometallic Compounds Anilides Indicators and Reagents General Chemistry Catalysis
Zdroj:	Chem. Eur. J.
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.202200295
Popis:	The synthesis of ketones through addition of organometallic reagents to aliphatic carboxylic acids is a straightforward strategy that is limited to organolithium reagents. More desirable Grignard reagents can be activated and controlled with a bulky aniline-derived turbo-Hauser base. This operationally simple procedure allows the straightforward preparation of a variety of aliphatic and perfluoroalkyl ketones alike from functionalized alkyl, aryl and heteroaryl Grignard reagents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8075cfe8adf912e95b26b52ed9c642b1 https://doi.org/10.1002/chem.202200295 Zobrazit plný text záznamu Plný text