Injectable Amniotic Membrane/Umbilical Cord Particulate for Knee Osteoarthritis: A Prospective, Single-Center Pilot Study

Autor: Sean Tighe, Ramon Castellanos
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Amniotic Membrane
WOMAC
Knee Joint
Population
Pain
Pilot Projects
Osteoarthritis
Knee Joint Pain
Umbilical cord
Injections
Intra-Articular
Umbilical Cord
03 medical and health sciences
0302 clinical medicine
Original Research Articles
medicine
Humans
Pain Management
education
Aged
Pain Measurement
030304 developmental biology
030203 arthritis & rheumatology
0303 health sciences
education.field_of_study
medicine.diagnostic_test
business.industry
REHABILITATION & REGENERATIVE MEDICINE SECTION
Magnetic resonance imaging
General Medicine
Middle Aged
Osteoarthritis
Knee
medicine.disease
Treatment Outcome
Orthopedics
Anesthesiology and Pain Medicine
Knee pain
medicine.anatomical_structure
Private practice
Anesthesia
Orthopedic surgery
Female
Neurology (clinical)
medicine.symptom
business
Zdroj: Pain Medicine: The Official Journal of the American Academy of Pain Medicine
ISSN: 1526-4637
1526-2375
DOI: 10.1093/pm/pnz143
Popis: Objective To evaluate the short-term safety and effectiveness of amniotic membrane/umbilical cord particulate (AMUC) in managing pain in patients with various severities of knee osteoarthritis (OA). Design Single-center, prospective, investigator-initiated pilot study. Setting Private practice. Subjects A total of 20 knee OA patients aged ≥18 years were enrolled with pain >40 mm, as determined by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)–A. Methods Patients received an ultrasound-guided, intra-articular injection of 50 mg of AMUC particulate reconstituted in 2 mL of preservative-free saline. All patients were then monitored at six weeks, 12 weeks, and 24 weeks postinjection. Patients who did not show >30% reduction in pain received a second injection of AMUC at six weeks. WOMAC, Patient Global Assessment, medication usage, and magnetic resonance imaging (MRI) were assessed. Results Knee OA pain significantly decreased from 74.3 ± 17.2 at baseline to 45.0 ± 25.4 at six weeks (P 30 kg/m2 (P = 0.025). MRI evaluation of the overall population revealed an improvement in the severity of bone marrow lesions in seven patients. No adverse events were observed. Conclusions AMUC particulate injection relieved pain and improved physical function in patients with symptomatic knee OA.
Databáze: OpenAIRE
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