Elevated haemoglobin A1c but not fasting plasma glucose conveys risk of chronic kidney disease in non-diabetic individuals
| Autor: | Keishi Yamauchi, Yuka Sato, Rimei Nishimura, Toru Aizawa, Tomomichi Koshi, Mitsuhiko Noda, Koh Yamashita, Hideo Koike, Hiroyuki Sagesaka, Kazuko Hirabayashi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Renal function 030209 endocrinology & metabolism 030204 cardiovascular system & hematology urologic and male genital diseases Gastroenterology Cohort Studies Prediabetic State 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans Prediabetes Renal Insufficiency Chronic Retrospective Studies Glycated Hemoglobin Plasma glucose business.industry Hazard ratio nutritional and metabolic diseases Fasting General Medicine Middle Aged medicine.disease Cohort Female business Non diabetic Kidney disease |
| Zdroj: | Diabetes Research and Clinical Practice. 146:233-239 |
| ISSN: | 0168-8227 |
| Popis: | Aims To compare impact of elevated HbA1c and fasting plasma glucose (FPG) on incident chronic kidney disease (CKD) in a non-diabetic cohort. Methods Data from diabetes- and CKD-free 25,109 health examinees were retrospectively analysed with a mean observation period of 5.3 years. Prediabetes was diagnosed by the ADA and WHO criteria, and CKD by estimated glomerular filtration rate (eGFR) Results For incident CKD (n = 2483), high HbA1c but not FPG was an independent risk: adjusted hazard ratio (AHR, 95%CI) for HbA1c 1% and FPG 1 mmol/L, 1.91 (1.70–2.16) and 0.85 (0.60–1.20), respectively. Prediabetes by the ADA and WHO criteria were both risk for CKD with AHR (95%CI), 1.21 (1.12–1.32) and 1.31 (1.16–1.48), respectively. Prediabetes diagnosed by ‘elevated HbA1c irrespective of FPG’, either by the ADA and the WHO definition, was a risk with AHR (95%CI), 1.48 (1.36–1.61) and 1.51 (1.31–1.74), respectively. In contrast, prediabetes diagnosed by ‘raised FPG irrespective of HbA1c’ was not a CKD risk. Conclusions Elevated HbA1c, but not FPG, identified CKD risk in non-diabetic individuals. |
| Databáze: | OpenAIRE |
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