Prevention of Aflatoxin B1 Hepatoxicity by Dietary Selenium Is Associated with Inhibition of Cytochrome P450 Isozymes and Up-Regulation of 6 Selenoprotein Genes in Chick Liver
| Autor: | Lv Hui Sun, Ji Chang Zhou, De Sheng Qi, Ming Kun Zhu, Ni Ya Zhang, Ling Zhao |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant GPX3 medicine.medical_treatment Medicine (miscellaneous) 010501 environmental sciences 01 natural sciences Isozyme 03 medical and health sciences Internal medicine medicine education 0105 earth and related environmental sciences Liver injury chemistry.chemical_classification education.field_of_study Nutrition and Dietetics Selenoprotein N Chemistry Glutathione peroxidase medicine.disease Molecular biology 030104 developmental biology Endocrinology Iodothyronine deiodinase Selenoprotein |
| Zdroj: | The Journal of Nutrition. 146:655-661 |
| ISSN: | 0022-3166 |
| DOI: | 10.3945/jn.115.224626 |
| Popis: | BACKGROUND The involvement of cytochrome P450 (CYP450) isozymes and the selenogenome in selenium-mediated protection against aflatoxin B1 (AFB1)-induced adverse effects in broilers remains unclear. OBJECTIVE This study was designed first to determine whether selenium could reduce AFB1-induced hepatotoxic effects and then to determine whether these effects were due to changes in the CYP450 isozymes and selenogenome expression in the liver of chicks. METHODS Male avian broilers (aged 120 d) were allocated to 4 groups with 5 replicates of 6 birds to be included in a 2-by-2 factorial trial in which the main factors included supplementation of AFB1 ( |
| Databáze: | OpenAIRE |
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