Primary intranasal perivascular wall tumors in 2 cats
| Autor: | Francesco Godizzi, Giancarlo Avallone, Gabriele Ghisleni, Silvia Dell’Aere, Clarissa Zamboni, Paola Valenti, Paola Roccabianca |
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| Rok vydání: | 2022 |
| Předmět: |
General Veterinary
intranasal PDGFRβ nasal Soft Tissue Neoplasms glomangiopericytoma Glomus Tumor Cat Diseases Immunohistochemistry Dogs cats hemangiopericytoma immunohistochemistry perivascular wall tumor sinonasal hemangiopericytoma-like tumor solitary fibrous tumor Cats Biomarkers Tumor Animals Humans Dog Diseases Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria Settore VET/08 - Clinica Medica Veterinaria Hemangiopericytoma |
| Zdroj: | Journal of Veterinary Diagnostic Investigation. 35:81-86 |
| ISSN: | 1943-4936 1040-6387 |
| DOI: | 10.1177/10406387221140074 |
| Popis: | Perivascular wall tumors (PWTs) are common well-known canine mesenchymal tumors. The term PWT has not yet been applied to cats; only 2 cases of feline soft tissue hemangiopericytomas (HEPs) are available. In human medicine, sinonasal HEP-like tumor/glomangiopericytoma (SHPCL/GP) and intranasal solitary fibrous tumor (SFT) are well-known mesenchymal tumors with staghorn vasculature and low malignant potential; however, these entities have not been described in small animals. We describe here the pathologic and immunohistochemical features of 2 cases of feline intranasal mesenchymal tumors consistent with PWTs and resembling human SHPCL/GP (case 1), and human intranasal SFT (case 2). Both cats developed intranasal, unilateral, polypoid, expansile neoplasms with a mostly patternless growth of spindle cells, minimal stroma, and prominent staghorn vessels. The stroma was PAS negative, which excludes a glomus tumor. Immunohistochemistry identified diffuse vimentin and PDGFRβ expression. Case 1 was α-SMA positive (as is human SHPCL/GP); case 2 was negative (as is human intranasal SFT). Both tumors were incompletely excised, leading to recurrence in case 1. Case 2 was lost to follow up. To our knowledge, intranasal PWTs have not been reported previously in cats. The frequency of the lesions is not known, but awareness of these entities may assist in their recognition and better characterization in the future. |
| Databáze: | OpenAIRE |
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